- Title
- Estimating the glomerular filtration rate in pregnancy: the evaluation of the Nanra and CKD-EPI serum creatinine-based equations
- Creator
- Gao, Michael; Vilayur, Eswari; Ferreira, David; Nanra, Ranjit; Hawkins, Joan
- Relation
- Obstetric Medicine Vol. 14, Issue 1, p. 31-34
- Publisher Link
- http://dx.doi.org/10.1177/1753495X20904177
- Publisher
- Sage
- Resource Type
- journal article
- Date
- 2021
- Description
- Aim: To compare the performance of the Nanra and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating glomerular filtration rate in pregnancy against the 24 h urine creatinine clearance. Methods: Pregnant women had 24 h urine collections with simultaneous serum creatinine levels. Measured 24 h urine creatinine clearance was compared to two equations: Nanra and CKD-EPI. Level of concordance was measured, with an a priori bias acceptance of ±15 ml/min/1.73 m2. Results: A total of 53 synchronous urine and serum creatinine samples were analysed. The Nanra equation had a bias of -13.4 ml/min/1.73 m2 while the CKD-EPI equation had bias of 14.2 ml/min/1.73 m2. Both equations showed a high degree of proportional error and had poor agreement with 24 h urine creatinine clearance. Conclusions: None of the equations were shown to reliably measure the estimated glomerular filtration rate in pregnant women. A valid serum creatinine-based estimated glomerular filtration rate equation in pregnancy is yet to be established.
- Subject
- glomerular filtration rate; pregnancy; serum creatinine; creatinine clearance; Nanra; CKD-EPI; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1462177
- Identifier
- uon:46402
- Identifier
- ISSN:1753-495X
- Language
- eng
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